Description
MOTS-C Research Peptide
MOTS-C is a 16-amino acid mitochondrial-derived peptide (MDP) encoded within the mitochondrial 12S rRNA gene. It’s one of the most actively studied mitochondrial peptides in the metabolic research literature, with growing interest in its role as an AMPK pathway activator and cellular stress-response mediator.
Under conditions of metabolic stress, MOTS-C has been observed to translocate to the nucleus where it influences the expression of stress-protective and antioxidant genes. That nuclear translocation behavior is part of what makes it such a compelling research target — it bridges mitochondrial signaling and nuclear gene regulation in ways researchers are still working to fully characterize.
Scientific Profile
- Molecular Formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂
- Molecular Weight: ~2174.6 g/mol
Key Research Areas
- AMPK Pathway Activation: Studied for its effects on AMPK-mediated signaling and cellular energy substrate utilization
- Nuclear Translocation: Migrates to the nucleus under metabolic stress conditions, influencing protective gene expression programs
- Mitochondrial Signaling: One of a small family of mitochondrial-derived peptides linking organelle function to systemic signaling
- Skeletal Biology: Investigated for effects on osteoblast activity and collagen synthesis in bone tissue research models
Quality & Testing
Every vial is independently tested at a US-accredited lab. HPLC for purity. Mass spec for identity. Endotoxin testing included. Your Certificate of Analysis ships with your order — not buried on a webpage, right there in the box.
Storage
- Lyophilized Powder: Store below freezing for optimal stability
- Prepared Solution: Refrigerate at 2-8°C. Best results within 30 days of preparation
⚠ FOR RESEARCH USE ONLY. NOT INTENDED FOR HUMAN OR VETERINARY CONSUMPTION.
